I just finished attending my first PyOhio and I have to say that I enjoyed it. It was interesting to see so many people involved enough in their interests to spend a weekend talking about code. There were sessions geared to all levels of Python knowledge and a wealth of knowledge to be shared.
I am a Python novice so my ability to hang in on the deeper side discussions was limited, but I came away with much more information and a bunch of areas to dig into deeper.
If you are in the Ohio area and even slightly interested in Python I would recommend you keep an eye out for PyOhio 2010.